Make a Girl: High school student Akira Mizutane, whose mother is a genius scientist, spends his days trying to follow in his mother's footsteps. However, he feels that he has reached a dead end in his research and becomes depressed, thinking that he doesn't have the talent his mother has. One day, Akira is advised by a friend that a man can become more powerful by having a girlfriend, so he creates an artificial human girlfriend, "No. 0".