Trails of the Golden West: A wagon train of "Forty-Niners" heading for the California gold fields includes a girl, her father and an old black servant, who have hidden their family jewels and life savings in their wagon. One of the men in the train plots with some Indians to attack the caravan and steal the family's wealth. In order to isolate their wagon, the villain has one of his men pose as a small pox victim so that the wagon train will leave them behind. After they fight with the Indians and the band of outlaws, the girl and her family are saved by the leader of the wagon train.