Drums of Africa: David Moore is in East Africa to get to his employer's railway construction site. He's accompanied by the owner's son Brian and they've lined up Jack Cuortemayn, reputedly the best guide available, to take them there. Cuortemayn refuses as he doesn't care for the impact the railroad will have on the local inhabitants. While Moore tries to make other arrangements, he meets Ruth Knight who has lived there for many years working with her father in a medical clinic. There will be adventures along the way but when Ruth is captured by slave traders, it's up to the others to rescue her.