My Sister Eileen: Sisters Ruth and Eileen Sherwood move from Ohio to New York in the hopes of building their careers. Ruth wants to get a job as a writer, while Eileen hopes to succeed on the stage. The two end up living in a dismal basement apartment in Greenwich Village, where a parade of odd characters are constantly breezing in and out. The women also meet up with magazine editor Bob Baker, who takes a personal interest in helping both with their career plans.